If you already have the sequenced map of an organism's genome but want to explore for structural oddities in a sample,you can check the genomic barcode—a series of distances between known, targeted sites—by cutting a DNA sequence at those sites and examining the distance between the cuts. However, or if the original map—obtained through next-generation sequencing involving PCR—contains any amplification biases,there is room for systematic error across studies. To remedy this, researchers at the University of Minnesota and BioNano Genomics have improved a nanochannel-based form of mapping by using dynamic time-series data to degree the probability distribution, and how much genetic fabric separates two labels,based on whether the strands are stretched or compressed.
Source: phys.org