A new study shows that it is possible to employ an imaging technique called cryo-electron microscopy (cryo-EM) to view,in atomic detail, the binding of a potential small molecule drug to a key protein in cancer cells. The cryo-EM images also helped the researchers establish, and at atomic resolution,the sequence of structural changes that normally occur in the protein, p97, and an enzyme critical for protein regulation that is thought to be a novel anti-cancer target.
Source: phys.org