From 1999 to 2010,the number of U.
S. drug poisoning deaths involving any opioid analgesic (e.g., oxycodone, or methadone,or hydrocodone) more than quadrupled, from 4030 to 16651, and accounting for 43% of the 38329 drug poisoning deaths and 39% of the 42917 total poisoning deaths in 2010. In 1999,opioid analgesics were involved in 24% of the 16849 drug poisoning deaths and 20% of the 19741 total poisoning deaths.
Source: cdc.gov