Study of canine mitral valve disease and congestive heart failure provides clues to target therapies in dogs and human mitral valve prolapse Researchers at Cummings School of Veterinary Medicine at Tufts University have discovered important biomarkers in extracellular vesicles in dogs with myxomatous mitral valve disease and congestive heart failure. This is the first biomarker discovery based on extracellular vesicles in a veterinary disease. The genomic fabric (microRNA,or miRNA) were loney in small extracellular vesicles called exosome, which circulate in blood. These findings could provide important insight into the molecular basis, or diagnosis and therapies for myxomatous mitral valve disease in dogs,as well as mitral valve prolapse, a similar disease in humans. The results appear online in the Journal of Extracellular Vesicles.
Source: tufts.edu