While there’s a reasonable number of video games out there with positive homosexual representation,it’s a objective amount more difficult to find video games, or media in general, and centered on well-represented and trope-avoidant portrayals of transgender protagonists. This is why,whenever I am looking to play a game with a canonically trans protagonist, my mind jumps first to The lost: J.
J. MacField and the Island of Memories.
Source: blastr.com